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Its activity at the dopamine transporter is six times stronger than at the norepinephrine transporter and it is virtually inactive at theĀ serotoninĀ transporter.Ā MDPV remained an obscure stimulant until around 2004 when it was reportedly sold as a designer drug.
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In addition to its stimulant effects, mephedrone producesĀ side effects, of whichĀ bruxismĀ is the most common. TheĀ metabolismĀ of mephedrone has been studied in rats and humans and the metabolites can be detected in urine after usage.
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In low to moderate doses, methamphetamine canĀ elevate mood, increase alertness, concentration and energy in fatigued individuals, reduce appetite, and promote weight loss. At very high doses, it can induceĀ psychosis,Ā breakdown of skeletal muscle,Ā seizuresĀ andĀ bleeding in the brain. Chronic high-dose use can precipitate unpredictable and rapidĀ mood swings,Ā stimulant psychosisĀ (e.g.,Ā paranoia,Ā hallucinations,Ā delirium, andĀ delusions) andĀ violent behavior.
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methylone acts on monoaminergic systems.Ā In vitro, methylone has one third the potency of MDMA at inhibiting platelet serotonin accumulation and about the same in its inhibiting effects on the dopamine and noradrenaline transporters.
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It was also found in combination with 4-MePPP being sold as "NRG-3". Ā Reports indicate side effects include feelings of paranoia, agitation and inability to sleep, with effects lasting for several days at high doses.
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2C-E's effects are often described as "neutral", in comparison with other psychedelic chemicals and even otherĀ 2C-xĀ related molecules.
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Heroin, also known asĀ diacetylmorphineĀ andĀ diamorphineĀ among other names, is a morphinan opioid substance synthesized from the dried latex of the opium poppy; it is mainly used as a recreational drug for its euphoric effects.
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Alpha-PVP, also known as A-PVP, is a powerful stimulant and is usually taken to achieve euphoria. It is a synthetic stimulant drug of cathinone.
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Unlike many of the olderĀ JWH seriesĀ compounds, this compound does not have aĀ naphthalene ring, instead occupying this position with a 2'-methoxy-phenylacetyl group, making JWH-250 a representative member of a new class of cannabinoid ligands.
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Nembutal (pentobarbital sodium) is a barbiturate that acts as a depressant, or sedative, used short-time period to deal with insomnia
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