Pentobarbital Sodium (Nembutal) | 98% Pure

Pentobarbital Sodium (Nembutal) | 98%    Pentobarbital Sodium, a short-acting barbiturate derivative of barbituric acid, is a foundational compound in neuropharmacological and forensic research. Known chemically as sodium 5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6-triolate, this substance is primarily utilized as a potent central nervous system (CNS) depressant. Our analytical-grade Pentobarbital Sodium is synthesized to a guaranteed purity of ≥98%, providing the precision required for sophisticated in vitro and in vivo laboratory protocols.

The Scientific Gold Standard for Laboratory Research

For over a century, Pentobarbital Sodium has been a primary subject of study in sleep induction, sedation, and anticonvulsant research. In the modern laboratory environment, it serves as a critical reference standard for toxicologists and a reliable anesthetic agent for veterinary medical science. Our product is refined to minimize residual solvents and heavy metals, ensuring that your research results are reproducible and free from baseline interference.

1. Technical Specifications & Molecular Profile of Pentobarbital Sodium (Nembutal) | 98% Pure

Research integrity is built on molecular certainty. Our Pentobarbital Sodium is formulated as a high-stability salt, prioritized for its superior shelf-life and predictable solubility in polar solvents.

• Formal Name: Sodium 5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6-triolate

• Molecular Formula: $C_{11}H_{17}N_{2}NaO_{3}$

• Molecular Weight: 248.25 g/mol

• CAS Number: 57-33-0

• Analytical Purity: ≥98% (Verified via HPLC and Mass Spectrometry)

• Physical Form: Fine crystalline powder

• Solubility: Highly soluble in Water (approx. 100 mg/mL) and Ethanol.

2. Primary Applications of Pentobarbital Sodium (Nembutal) | 98% Pure in Forensic & Clinical Science

Forensic Toxicology and Reference Identification

Forensic laboratories rely on verified reference standards to validate their analytical methods. Pentobarbital Sodium is essential for:

• LC-MS/MS & GC-MS Calibration: Establishing definitive mass-to-charge ($m/z$) ratios for forensic libraries.

• Metabolic Profiling: Studying the hepatic degradation of barbiturates into secondary metabolites in post-mortem analysis.

• Matrix Differentiation: Distinguishing between barbiturate analogues in complex biological matrices.

Neuropharmacology and Veterinary Research

In veterinary and neuro-research, Pentobarbital is the primary agent for inducing controlled, dose-dependent sedation. Researchers utilize our high-purity powder for:

• Anticonvulsant Evaluation: Studying the suppression of acute convulsive episodes in animal models of status epilepticus.

• Pre-anesthetic Synergy: Investigating the interactions between barbiturates and emerging analgesic compounds.

• Physiological Baseline Studies: Establishing CNS baseline depressant effects in long-term pharmacological trials.

3. Quality Assurance:

We understand that the validity of your data is directly tethered to the quality of your reagents. To satisfy Google’s expertise requirements, we provide a “Gold Standard” verification package with every institutional order:

1. Batch-Specific Certificate of Analysis (CoA): Detailed proof of purity and structural identity via NMR and HPLC.

2. Analyte Verification: Our standards are cross-referenced with global databases (PubChem/ChemSpider) to ensure absolute structural alignment.

3. Low Residual Impurity: Minimized trace heavy metals and synthesis precursors to prevent interference in delicate in vitro assays.

4. Safety, Stability, and Regulatory Handling

Laboratory Use Only: This compound is intended strictly for forensic, diagnostic, or laboratory research purposes. It is NOT for human or veterinary clinical use without proper institutional licensing and professional supervision.

Storage & Stability

To maintain ≥98% purity, Pentobarbital Sodium must be handled with professional rigor:

• Standard Storage: Store in a cool, dry environment at 20°C to 25°C (68°F to 77°F).

• Hygroscopic Management: Keep containers tightly sealed to prevent moisture absorption, which can alter the weight and concentration of prepared solutions.

• Thermal Sensitivity: Pharmaceutical-grade reagents must be protected from excessive heat and freezing to prevent degradation of the barbiturate salt.

Safety Protocols

Pentobarbital Sodium is a potent CNS depressant. Standard laboratory PPE is mandatory. This includes nitrile gloves, safety goggles, and a lab coat. For comprehensive handling instructions, refer to the [Safety Data Sheet (SDS) for Pentobarbital Sodium].

Crystalline chemical structure of Pentobarbital Sodium for analytical laboratory reference

5. Pharmacological Overview (Clinical Context)

Note: This section is provided for researchers studying the historical and clinical applications of pentobarbital.

Pentobarbital acts as a non-selective central nervous system depressant. Its primary mechanism involves the modulation of the GABA-A receptor complex, increasing the duration of chloride channel opening. Historically, it has been utilized as a:

• Hypnotic: Short-term treatment of insomnia (typically loses effectiveness after 14 days of continuous use).

• Preanesthetic: Administered to reduce anxiety and induce sedation prior to surgical intervention.

• Anticonvulsant: Utilized in anesthetic doses for the emergency control of acute convulsive episodes related to eclampsia, meningitis, or toxic reactions to local anesthetics.

6. Institutional Procurement & Compliance

Pentobarbital Sodium is a strictly regulated substance. Access is restricted to licensed research institutions, forensic labs, and government agencies.

Mandatory Requirements for Order Fulfillment:

• Verified Institutional Address: We ship exclusively to recognized university or government laboratory addresses.

• Regulatory Documentation: A copy of the valid institutional research license (e.g., DEA registration in the US or Home Office license in the UK) must be on file.

• Terms of Professional Use: By purchasing, the institution agrees that the reagent will be used exclusively for authorized research or forensic analysis.

7. Ordering & Logistics for Researchers

We provide scalable solutions to fit various research budgets and project sizes:

Procurement Note: For institutional orders exceeding 2.5 kilograms, please contact our specialized B2B procurement team for tiered pricing and cold-chain logistics coordination.

8. Frequently Asked Questions (FAQ) for Researchers

Q: Is the powder suitable for preparing injectable solutions?

A: Yes, our analytical powder is highly soluble in water. For researchers preparing parenteral solutions, ensure the pH is adjusted to approximately 9.5 with hydrochloric acid or sodium hydroxide to maintain stability, as per USP standards.

Q: Can you provide spectral data prior to shipping?

A: Absolutely. Our lab can provide a preliminary CoA for the current batch upon request to ensure it meets your specific analytical requirements.

Q: How do you handle international research shipments?

A: We provide all necessary documentation (Import/Export permits) to ensure compliant customs clearance for licensed institutions worldwide.